Association of interleukin-6 (-174G > C) promoter polymorphism with risk of squamous cell esophageal cancer and tumor location: An exploratory study

作者：Upadhyay Rohit; Jain Meenu; Kumar Shaleen; Ghosha Uday Chand; Mittal Balraj^*

来源：Clinical Immunology, 2008, 128(2): 199-204.

DOI：10.1016/j.clim.2008.03.519

• interleukin-6 gene polymorphism
• inflammation
• cancer risk
• esophageal cancer
• cancer susceptibility

Chronic inflammation plays a rote in transformation from normal cell to malignant state. Interleukin-6 (IL-6) regulates inflammation and various physiological processes. IL-6 promoter polymorphism (-174G > C) is associated with transcription differences in vitro and in vivo. High expression of IL-6 may result in oxidative DNA damage and enhance risk of carcinogenesis. Therefore, we aimed to evaluate association of IL-6 -174G > C polymorphism with predisposition to esophageal cancer (EC) in 369 subjects (168 patients with EC and 201 controls). We observed significant association of IL-6 -174C non-carrier genotype with risk of EC, (OR=2.29; P=0.001), with squamous cell carcinoma (SCC) histology (OR=2.26; P=0.001) and tumor at upper and lower anatomical locations (OR=5.97; P=0.009 and OR=2.34; P=0.034). Patients having IL-6 -174C non-carrier genotype were at elevated risk of metastasis (OR=2.49; P=0.005). In conclusion, IL-6 -174G > C gene polymorphism may confer high risk for EC and its clinical characteristics.

• 出版日期2008-8
• 单位河北医科大学