A Waterborne Outbreak of Shigella sonnei with Resistance to Azithromycin and Third-Generation Cephalosporins in China in 2015

作者：Ma, Qiuxia; Xu, Xuebin; Luo, Ming; Wang, Jian; Yang, Chaojie; Hu, Xiaofeng; Liang, Beibei; Wu, Fuli; Yang, Xiaoxia; Wang, Jinyan; Liu, Hongbo; Li, Wen; Zhong, Yu; Li, Peng; Xie, Jing; Jia, Leili; Wang, Ligui; Hao, Rongzhang; Du, Xinying; Qiu, Shaofu^*; Song, Hongbin^*; Sun, Yansong^*

来源：Antimicrobial Agents and Chemotherapy, 2017, 61(6): e00308-17.

DOI：10.1128/AAC.00308-17

• Shigella sonnei
• multidrug resistance
• outbreak
• waterborne

Here, we report for the first time a waterborne outbreak of Shigella sonnei in China in 2015. Eleven multidrug-resistant (MDR) S. sonnei isolates were recovered, showing high resistance to azithromycin and third-generation cephalosporins in particular, due to an mph(A)-and bla(CTX-M-14)-harboring IncB/O/K/Z group transmissible plasmid of 104,285 kb in size. Our study highlights the potential prevalence of the MDR outbreak of S. sonnei in China and its further dissemination worldwide with the development of globalization.

• 出版日期2017-6
• 单位中国人民解放军军事医学科学院; 上海市疾病预防控制中心