科研之友
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摘要
In recent years water soluble cationic polymers are gaining more and more interest in different applications ranging from hair conditioning to gene transfection and drug delivery. The molecular weight distribution of polymers is usually characterized by SEC coupled with refractive index, viscometric or laser light scattering detection. A challenge in aqueous SEC analysis of cationic polymers is the interaction between sample molecules and the packing material, which disturbs separation efficiency and reproducibility.(1,2) Interactions can be suppressed with high salt eluents but at the risk of precipitation and poor recovery of the sample. We describe the separation of cationic polymers with a new generation of SEC columns, developed for the analysis of cationic polymers at low salt conditions.
- 出版日期2008-3
