Adiponectin gene 45T > G polymorphism is not associated to plasma adiponectin in a cohort of patients with type 2 diabetes from Romania

作者：Kacso Ina M^*; Trifa Adrian P; Popp Radu A; Bondor Cosmina I; Farcas Marius F; Lenghel Alina R; Moldovan Diana; Rusu Crina; Nita Cristina; Pop Ioan V; Gherman Caprioara M; Hancu Nicolae D

来源：Revista Romana de Medicina de Laborator, 2012, 20(1): 73-79.

• adiponectin
• gene polymorphism
• type 2 diabetes

Background: We aimed to evaluate the prevalence of 45T>G polymorphism of the ADIPOQ gene in a cohort of type 2 diabetes patients from Romania. The influence of the polymorphism on adiponectinemia and its relationship to presence of albuminuria were also assessed. Materials and methods: 115 type 2 diabetic patients were genotype.] for the ADIPOQ 45T>G polymorphism. Medical history, laboratory evaluation and total plasma adiponectin were obtained. Results: TT genotype occurred in 101 (87.82%) patients, TG genotype in 12 (10.43%) and GG genotype in 2(1.73%) subjects. Genotypes for the 45T>G polymorphism were not significantly associated to plasma adiponectin. Patients were divided according to the presence of albuminuria in albuminuric patients (albumin/creatinine ratio> 30 mg/g creatinine) and normoalbuminuric (albumin/creatinine ratio< 30 mg/g creatinine). Albuminuric patients had significantly higher adiponectin levels (14.58 +/- 1.07 versus 6.91 +/- 0.84 mu g/ml); however there was no difference in genotype distribution between normoalbuminuric and albuminuric patients (p=0.61). Logistic regression showed that systolic blood pressure p=0.044 (OR 1.04; CI 1.01/1.08), adiponectin p=0.03 (OR 1.07; CI 1.00/1.14) and age p=0.07 (OR 1.05; CI 0.99/1.12), but not genotype are predictors of albuminuria. Conclusion: The ADIPOQ 45T>G polymorphism did not influence plasma adiponectin levels in a cohort of patients with type 2 diabetes from Romania.

• 出版日期2012-3