Antioxidant and alpha-Glucosidase Inhibitory Activities of Isolated Compounds from Ipomoea aquatica

作者：Lawal Umar; Shaari Khozirah; Ismail Intan Safinar; Khatib Alfi; Abas Faridah^*

来源：Records of Natural Products, 2016, 10(6): 701-707.

• Antioxidant activity
• total phenolic content
• alpha-glucosidase inhibition
• spectral analysis

Ipomoea aquatica Forsk is a green leafy vegetable that is a rich source of amino acids and vitamins. Antioxidant and alpha-glucosidase inhibitory activities of the hexane (IAHE) and methanol (IAME) fractions of the vegetable portion of I. aquatica were investigated. The IAME fraction exhibited a strong scavenging effect of the 2,2-diphenyl-2-picryl hydrazyl (DPPH) free radicals, and this fraction contained the highest phenolic contents. Phytochemical investigation of the IAME fraction yielded three known compounds, namely 3,5-di-O-caffeoylquinic acid (1), 4,5-di-O-caffeoylquinic acid (2) and quercetin 3-O-beta-D-glucoside (3). The structures were unambiguously elucidated based on 1D and 2D-NMR analyses (1H, 13C, COSY, HSQC, HMBC) and mass spectrometry data. Compound 3 was isolated for the first time from this plant.

• 出版日期2016