Population genetics of autosomal polymorphisms

作者：Schneider P M^*

来源：Medizinische Genetik, 2008, 20(3): 298-301.

DOI：10.1007/s11825-008-0127-6

• Genotype
• Forensic genetics
• Hardy-Weinberg equilibrium
• Biostatistics
• Population genetic parameters

For the collection of population data for DNA polymorphisms commonly used in forensic genetics, a number of criteria have to be considered, including the polymorphic marker and the detection method. Population frequencies can be compared only if a reproducible allelic discrimination as well as a generally accepted nomenclature have been established. Genetic validation includes the proof of Mendelian inheritance and knowledge of mutation rates. Sample donors for population studies should be selected at random, and the results need to be verified for the presence of Hardy-Weinberg equilibrium. A generally accepted definition of populations in the context of forensic applications is still missing and is the subject of ongoing discussion. For practical reasons, the selection of sample donors is currently based only on the donors' geographic origin. Furthermore, population genetic parameters such as FST and T should be used as correction factors for possible inhomogeneities in the study populations in the context of biostatistical evaluations.

• 出版日期2008-9