MRZH reaction increases sensitivity for intrathecal IgG synthesis in IgG Oligoclonal band negative Multiple Sclerosis patients

作者：Dias Carneiro Rafael P C^*; von Glehn Felipe; Moraes Adriel S; Boldrini Vinicius O; Damasceno Alfredo; Andrade Marilia D; Lima Alliny C D; Casanova Cristiane S; Tilbery Charles P; Damasceno Benito P; dos Santos Leonilda M B; Brandao Carlos O

来源：Journal of Neuroimmunology, 2016, 300: 30-35.

DOI：10.1016/j.jneuroim.2016.10.001

• Multiple Sclerosis
• Cerebrospinal Fluid
• Oligoclonal bands
• Polyspecific antibodies
• Brazil
• Intrathecal synthesis

Given the low detection rates of CSF IgG-Oligoclonal bands (IgG-OCB) in non-European Multiple Sclerosis (MS) patients and higher specificity of the MRZH-reaction, we evaluated whether associating MRZH-reaction to CSF IgG-OCB detection improved investigation of suspected MS. Paired CSF and sera were analyzed for IgG-OCB and polyspecific viral antibodies. IgG-OCB were detected in 72% of MS patients and an MRZH-reaction in 67%. Combining lgG-OCB and MRZH raised detection of IgG abnormalities to 97% of studied MS patients. Detection of lgG-OCB and/or >= MRZH antibodies showed sensitivity of 88% and specificity of 92% for MS, versus 72% and 96% for IgG-OCB alone.

• 出版日期2016-11-15