Association of serum levels of perfluoroalkyl substances with gestational diabetes mellitus and postpartum blood glucose

作者：Wang Yuxin; Zhang Lei; Teng Yue; Zhang Jiayu; Yang Lin; Li Jingguang; Lai Jianqiang^*; Zhao Yunfeng; Wu Yongning

来源：Journal of Environmental Sciences, 2018, 69(07): 5-11.

DOI：10.1016/j.jes.2018.03.016

• Perfluoroalkyl substances
• Gestational diabetes mellitus
• Blood glucose

This study was conducted to examine the association of perfluoroalkyl substance (PFAS) exposure with gestational diabetes mellitus (GDM) risk and postpartum fasting blood glucose. We used a 1: 2 matched case-control study with 84 GDM subjects and 168 healthy pregnant women from Beijing, China. The maternal blood was collected at 1-2 days before delivery, and eight linear isomers and fourteen branched isomers were determined in maternal serum. Logistic regression analyses were performed to evaluate the associations after adjusting for potential confounders. The median of the sum of levels of total PFASs was 4.24 ng/mL with a interquartile range (IQR) of 2.82-6.54 ng/mL. Although maternal PFAS exposure was not associated with risk of GDM, significant positive associations were observed between evaluated exposure to specific PFAS congeners and increasing blood glucose. The odds ratio (ORs) of the highest category of postpartum fasting blood glucose for perfluoro-1-metylheptylsulfonat (1m-PFOS), perfluoro-3/4-metylheptylsulfonat (3m+4m-PFOS), perfluoro-5-metylheptylsulfonat (5m-PFOS), and perfluorohexane sulfonate (PFHxS) were 2.03 (95% CI: 1.09-3.77), 1.93 (95% CI: 1.04-3.58), 2.48 (95% CI: 1.33-4.65), and 2.26 (95% CI: 1.21-4.21), respectively, suggesting negative effects of maternal exposure to specific PFAS compounds on glucose metabolism.

• 出版日期2018-7
• 单位中国疾病预防控制中心; 国家食品安全风险评估中心