A new and efficient method for the protection of alcohols and phenols by using hexamethyldisilazane in the presence of anhydrous ferric chloride under mild reaction conditions

作者：Akhlaghinia Batool^*

来源：Phosphorus, Sulfur, and Silicon and the Related Elements, 2007, 182(3): 687-694.

DOI：10.1080/10426500601047487

• alcohol
• ferric chloride
• hexamethyldisilazane HMDS
• phenol
• trimethylsilylether

Alcohols and phenols are protected with hexamethyldisilazane in the presence of anhydrous ferric chloride in good to excellent yields in acetonitrile. This method is highly selective for the conversion of primary alcohols in the presence of secondary and tertiary alcohols and also for conversion phenols.

• 出版日期2007-3