Trajectory and risk factors for chemotherapy-induced nausea and vomiting in Asian patients with head and neck cancer

作者：Chan Alexandre^*; Shwe Maung; Gan Yanxiang; Yap Kevin; Chew Lita; Lim Wan Teck

来源：Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 2015, 37(9): 1349-1357.

DOI：10.1002/hed.23753

• head and neck cancer
• chemotherapy-induced nausea and vomiting
• antiemetics
• cancer
• chemotherapy

BackgroundThe purpose of this study was to analyze the trajectory of and risk factors for chemotherapy-induced nausea and vomiting in Asian patients with head and neck cancer.
MethodsAdult patients with head and neck cancer scheduled to receive cisplatin-based chemotherapy were recruited for the study. Clinical events were collated from standardized diaries.
ResultsTwo hundred thirty-five patients were included in the analyses. The majority (75.7%) was men, Chinese (81.7%), and manifested nasopharyngeal cancer (83.4%). The overall incidence of significant nausea and vomiting was 73.7% and 24.7%, respectively, with single-day cisplatin regimens of 48.9% and 28.9%, respectively, with the multiple-day cisplatin regimen. Patients using complementary alternative medicine were less likely than others to achieve a complete response to antiemetics.
ConclusionAlthough postchemotherapy vomiting is relatively well controlled in Asian patients with head and neck cancer, postchemotherapy nausea remains problematic in this population.

• 出版日期2015-9