Arginine deprivation in cancer therapy

作者：Feun Lynn G^*; Kuo Macus Tien; Savaraj Niramol

来源：Current Opinion in Clinical Nutrition and Metabolic Care, 2015, 18(1): 78-82.

DOI：10.1097/MCO.0000000000000122

• Arg
• arginase
• Arg deiminase
• cancer

Purpose of review
There has been an increased and renewed interest in metabolic therapy for cancer, particularly Arg deprivation. The purpose of this review is to highlight recent studies that focus on Arg-dependent malignancies with Arginine (Arg)-degrading enzymes, including arginase and Arg deiminase.
Recent findings
New developments in this area include understanding of the role of most significantly downregulated gene regulating amino acid metabolism, argininosuccinate synthetase and its expression and therapeutic relevance in different tumors. Recent studies have also shed light on the mechanism of tumor cell death with Arg deprivation, with arginase and pegylated Arg deiminase. Particularly important is understanding the mechanism of resistance that cancers develop after such drug exposure. Finally, recent clinical trials have been performed or are ongoing to use Arg deprivation as treatment for advanced malignancies.
Summary
Arg deprivation is a promising approach for the treatment of various malignancies.

• 出版日期2015-1