A multicenter comparative study of UCu200, TCu380A, and medicated gamma-IUD devices inserted immediately after vacuum aspiration

作者：Hu, Xiaopu; Li, Li; Zou, Yan; Wu, Shangchun^*

来源：International Journal of Gynecology & Obstetrics, 2013, 122(1): 65-69.

DOI：10.1016/j.ijgo.2013.02.016

• Medicated gamma-IUD
• Post-abortion insertion
• Randomized clinical trial
• TCu380A
• UCu200

Objective: To compare safety and efficacy among 3 types of intrauterine device (IUD), namely UCu200, TCu380A, and medicated gamma-IUD, when inserted after vacuum aspiration. Methods: In a multicenter randomized comparative study, 1800 parous women requesting an IUD were enrolled in 12 centers across China in 2004-2005. The women received 1 of the 3 types of IUD and were followed-up for 12 months. Results: Among the participants, 596 received the UCu200, 591 received the TCu380A, and 594 received the medicated gamma-IUD. No pregnancy occurred during the follow-up period. The expulsion rate was 4.13 per 100 women (95% confidence interval [CI], 0.83-5.75) for the UCu200, 5.16 (95% CI, 0.92-6.96) for the TCu380A, and 2.73 (95% CI, 0.67-4.05) for the medicated gamma-IUD. The rate of medical removal of the UCu200, TCu380A, and medicated gamma-IUD was 3.60 (95% CI, 0.77-5.11), 225 (95% CI, 0.62-3.46), and 1.02 (95% CI, 0.41-1.83), respectively. Conclusion: Immediate insertion of the device after vacuum aspiration was found to be safe and effective for all 3 types of IUD. Compared with the other IUDs, the medicated gamma-IUD had a lower rate of medical removal and might be the most appropriate for broad use.

• 出版日期2013-7
• 单位国家卫生计生委科学技术研究所; 武汉大学