ER stress-induced inflammation: does it aid or impede disease progression?

作者：Garg Abhishek D; Kaczmarek Agnieszka; Krysko Olga; Vandenabeele Peter; Krysko Dmitri V^*; Agostinis Patrizia

来源：Trends in Molecular Medicine, 2012, 18(10): 589-598.

DOI：10.1016/j.molmed.2012.06.010

• ER stress
• cancer
• inflammation
• obesity
• diabetes
• inflammatory bowel disease
• immunity
• therapeutics
• airway disease

Different lines of research have revealed that pathways activated by the endoplasmic reticulum (ER) stress response induce sterile inflammation. When activated, all three sensors of the unfolded protein response (UPR), PERK, IRE1, and ATF6, participate in upregulating inflammatory processes. ER stress in various cells plays an important role in the pathogenesis of several diseases, including obesity, type 2 diabetes, cancer, and intestinal bowel and airway diseases. Moreover, it has been suggested that ER stress-induced inflammation contributes substantially to disease progression. However, this generalization can be challenged at least in the case of cancer. In this review, we emphasize that ER stress can either aid or impede disease progression via inflammatory pathways depending on the cell type, disease stage, and type of ER stressor.

• 出版日期2012-10
• 单位KU Leuven