Microwave-assisted organocatalysis: phosphine-mediated Tomita Zipper cyclization affording functionalized spirooxindole

作者：Zhang, Xiao-Yan; Shen, Ze; Hu, Li-Li; Wang, Liang-Jun; Lin, You-Shuai; Xie, Jian-Wu^*; Cui, Hai-Lei^*

来源：Tetrahedron Letters, 2016, 57(33): 3790-3794.

DOI：10.1016/j.tetlet.2016.07.035

• Tomita Zipper cyclization
• Microwave
• Phosphine
• Spirooxindole
• Dicyanomethylideneoxindole

A microwave-assisted and phosphine-mediated Tomita Zipper cyclization of dicyanomethylideneoxindoles and ynones has been developed. Various functionalized spirooxindoles with five-membered carbocyclic ring can be obtained in moderate to good yields with moderate to excellent diastereoselectivities through in situ generation of alpha-nucleophile (up to 87% yield, >20:1 dr).

• 出版日期2016-8-17
• 单位浙江师范大学; 重庆文理学院