Agglomerate strength and dispersion of pharmaceutical powders

作者：Adi Santoso; Adi Handoko; Chan Hak Kim^*; Finlay Warren H; Tong Zhenbo; Yang Runyu; Yu Aibing

来源：Journal of Aerosol Science, 2011, 42(4): 285-294.

DOI：10.1016/j.jaerosci.2011.02.002

• Agglomerate strength
• Mannitol
• Dry powder inhalation
• Aerosol
• Storage humidity

This study aims to investigate quantitatively the direct correlation between the mechanical strength of powder agglomerates and their dispersion into aerosols by a dry powder inhaler. Agglomerates of mannitol as a model drug-only formulation were prepared by a rolling method followed by exposure to various relative humidity (RH: 55%, 82%, 86% and 90%). The agglomerate strength was obtained from the compression of single agglomerates at a selected speed rate using an Instron testing machine. The dispersion performance (FPFLoaded) was determined at flow rates of 60 and 1001 min(-1) using an Aeroliser (R)} coupled to a multistage liquid impinger. Results showed an inverse linear relationship between the agglomerate strength and the dispersion performance. An increase in strength from 3 to 183 kPa resulted in a significant drop (P < 0.05) of 18% in the FPFLoaded. Agglomerates containing 'solid bridges' exhibited higher strength (three to eight times) and lower FPF (5-15%, corresponding to 86% and 90% RH) compared to those containing 'liquid bridges'. These results have provided direct information on the agglomerate strength and its quantitative relationship with powder aerosol performance.

• 出版日期2011-4