Assessment of evidence for a protective role of vitamin D in multiple sclerosis

作者：Hanwell Heather E C^*; Banwell Brenda

来源：Biochimica et Biophysica Acta-Molecular Basis of Disease, 2011, 1812(2): 202-212.

DOI：10.1016/j.bbadis.2010.07.017

• Vitamin D
• Multiple Sclerosis
• Hill's Criteria

Evidence for a role of vitamin D insufficiency in determining risk in Multiple Sclerosis (MS) is supported by studies in both pediatric- and adult-onset patients. The potential role of vitamin D in modulating MS disease activity is an area of active clinical trials research, and the possibility of primary disease prevention with vitamin D supplementation in early life is an emerging concept. With Sir Austin Bradford Hill's criteria as a framework, the present review assesses the evidence for a causal relationship between vitamin D insufficiency and the pathobiology of MS, and discusses rationale for future clinical trials with vitamin D.

• 出版日期2011-2