A pilot outreach physiotherapy and dietetic quality improvement initiative reduces IV antibiotic requirements in children with moderate severe cystic fibrosis

作者：Ledger Sean J^*; Owen Elizabeth; Prasad S Ammani; Goldman Allan; Willams Jane; Aurora Paul

来源：Journal of Cystic Fibrosis, 2013, 12(6): 766-772.

DOI：10.1016/j.jcf.2013.01.003

• Exercise
• Physiotherapy
• Dietetics
• Cystic fibrosis

Background: At our hospital the current model of care for children with moderate-severe CF is focused on intensive inpatient intervention, regular outpatient clinic review and specialist outreach care as required. An alternative model providing more regular physiotherapy and dietetic outreach support, in addition to these specialist services, may be more effective.
Methods: 16 children (4 male; 12 female; mean age 10.9 +/- 2.93; range 4-15 years) who required >40 days of W antibiotics in the 12-months preintervention were enrolled. Physiotherapy included weekly-supervised exercise sessions, alongside regular review of home physiotherapy regimens. Dietetic management included 1-2 monthly monitoring of growth, appetite, intake and absorption, and nutrition education sessions.
Results: There was a 23% reduction in inpatient IV antibiotic requirement and 20% reduction in home IV antibiotic requirement during the intervention year. Cost-benefit analyses showed savings of 113,570. VO2peak increased by 4.9 nil-kg-min-1 (95%CI 1.01 to 8.71; p =0.02), and 10 m-MSWT distance and increment achieved increased by 229 m (95%CI 109 to 350; p<0.001) and 2 levels (95%CI 1 to 3; p<0.002) respectively. No significant differences in physiological and patient reported outcomes were demonstrated, although there was a possible trend towards improvement in outcomes when compared to the pre-intervention year.
Conclusion: This pilot programme demonstrated a reduction in IV and admission requirements with a cost benefit in a small group of children with moderate-severe CF. A fully powered clinical trial is now warranted.

• 出版日期2013-12