DROSOPHILA MELANOGASTER SHOW A THRESHOLD EFFECT IN RESPONSE TO RADIATION

作者：Antosh Michael; Fox David; Hasselbacher Thomas; Lanou Robert; Neretti Nicola; Cooper Leon N^*

来源：Dose-Response, 2014, 12(4): 551-581.

DOI：10.2203/dose-response.13-047.Antosh

• low dose radiation
• gene expression
• Drosophila melanogaster
• threshold effect

We investigate the biological effects of radiation using adult Drosophila melanogaster as a model organism, focusing on gene expression and lifespan analysis to determine the effect of different radiation doses. Our results support a threshold effect in response to radiation: no effect on lifespan and no permanent effect on gene expression is seen at incident radiation levels below 100 J/kg. We also find that it is more appropriate to compare radiation effects in flies using the absorbed energy rather than incident radiation levels.

• 出版日期2014