Aging affects high-density lipoprotein composition and function

作者：Holzer Michael; Trieb Markus; Konya Viktoria; Wadsack Christian; Heinemann Akos; Marsche Gunther^*

来源：Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 2013, 1831(9): 1442-1448.

DOI：10.1016/j.bbalip.2013.06.004

• Proteome
• Cardiovascular disease
• Paraoxonase
• Anti-oxidative activity

Most coronary deaths occur in patients older than 65 years. Age associated alterations in the composition and function of high-density lipoproteins (HDL) may contribute to cardiovascular mortality. The effect of advanced age on the composition and function of HDL is not well understood. %26lt;br%26gt;HDL was isolated from healthy young and elderly subjects. HDL composition, cellular cholesterol efflux/uptake, anti-oxidant properties and paraoxonase activity were assessed. We observed a 3-fold increase of the acute phase protein serum amyloid A, an increased content of complement 0 and proteins involved in endopeptidase/protease inhibition in HDL of elderly subjects, whereas levels of apolipoprotein E were significantly decreased. HDL from elderly subjects contained less cholesterol but increased sphingomyelin. Most importantly, HDL from elderly subjects showed defective antioxidant properties, lower paraoxonase 1 activity and was more rapidly taken up by macrophages, whereas cholesterol efflux capability was not altered. %26lt;br%26gt;These findings suggest that aging alters HDL composition, resulting in functional impairment that may contribute to the onset/progression of cardiovascular disease.

• 出版日期2013-9