Algorithm-Based Prediction of HIV-1 Subtype D Coreceptor Use

作者：Dina Julia^*; Raymond Stephanie; Maillard Anne; Le Guillou Guillemette Helene; Rodalec Audrey; Beby Defaux Agnes; Giraudeau Genevieve; Vallet Sophie; Mourez Thomas; Payan Christopher; Vabret Astrid; Ruffault Annick; Ferre Virginie; Izopet Jacques; Plantier Jean Christophe

来源：Journal of Clinical Microbiology, 2013, 51(9): 3087-3089.

DOI：10.1128/JCM.00798-13

We compared the coreceptor tropism-predicting performance of a specific genotypic algorithm for HIV-1 subtype D and that of the geno2pheno algorithm with different cutoffs. The D-specific algorithm and geno2pheno with a false-positivity rate cutoff of 2.5% had the same concordance with the phenotypic determination. The geno2pheno algorithm with a false-positivity rate cutoff of 2.5%, more sensitive but slightly less specific, seems to be an appropriate alternative.

• 出版日期2013-9