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摘要
A new steroid, 24 xi, 25-dimethyl-3 alpha-hydroxyl-cholest-5-ene-2 beta-ol sodium sulfate (1), together with a known steroid, 24 xi, 25-dimethyl-cholest-5-ene-2 beta, 3 alpha-diol disodium sulfate (2), was isolated from the ethanol extract of marine sponge Halichondria rugosa. Their structures were elucidated on the base of spectroscopic analysis. Both compounds showed cytotoxicity to four human cancer cell lines (BEL-7402, HT-29, SPC-A1 and U-251) with IC50 values between 6.5 and 23.1 mu M.
- 出版日期2007
- 单位中国人民解放军第二军医大学; 天津市中医药研究院附属医院
