科研之友
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摘要
Cantharellus cibarius is an edible mushroom with worldwide distribution. Because of its good radical scavenging and strong iron-chelating activity, this mushroom was nominated for assay of antihypoxic activity. Protective effects of Chanterelle extract against hypoxia-induced lethality in mice were evaluated by 3 experimental models of hypoxia: asphyctic, hemic, and circulatory. Antihypoxic activity was especially pronounced in the hemic model. The effect was dose dependent. C. cibarius extract (600 mg kg(-1)) kept the mice alive for 10.07 +/- 1.18 min. It significantly (P < 0.0001) and dose dependently prolonged survival time compared to control group (7.00 +/- 0.63 min). Extract at 300 mg kg(-1) prolonged survival time to 9.94 +/- 0.87 min, which was statistically significant (P < 0.0001) compared to control group. In circulatory model, C. cibarius extract (600 mg kg(-1)) was effective. It prolonged latency for death significantly with regard to the control group (15.18 +/- 4.21 vs. 9.84 +/- 0.75 min; P < 0.001). At 300 mg kg-1, the extract also prolonged survival time (13.57 +/- 0.87 min), and this effect was also statistically significant compared to the control group (P < 0.01). Extract showed no activity in the asphyctic model. Mice in the control group died of hypoxia in 28.20 +/- 3.27 min. Extract (600 mg kg(-1)) prolonged latency for death, but this activity was not statistically significant (P > 0.05). Phenytoin prolonged latency for death to 55.00 +/- 6.05 min (P < 0.0001).
- 出版日期2014
