A cross-sectional analysis of candidate biomarkers of biological effect in smokers, never-smokers and ex-smokers

作者：Haswell Linsey E; Papadopoulou Ermioni; Newland Nik; Shepperd Christopher J; Lowe Frazer J^*

来源：Biomarkers, 2014, 19(5): 356-367.

DOI：10.3109/1354750X.2014.912354

• Biomarkers
• cancer
• cardiovascular disease
• COPD
• inflammation
• oxidative stress
• smoking
• toxicant

Context: Biomarkers of biological effect (BOBE) have been proposed as potential tools to assess tobacco product use, toxicity and disease risk.
Objective: To determine if candidate BOBE can distinguish between smokers, never-smokers and former smokers.
Methods: Biomarker levels were compared from 143 smokers, 61 never-smokers and 61 ex-smokers.
Results: In total, 27 candidate biomarkers were assessed, 14 were significantly different between smokers and never-smokers (p<0.01) and of these 14 biomarkers, 12 were able to distinguish between smokers and former smokers (p<0.05), which indicates the potential for reversibility.
Conclusions: A total of 12 of 27 BOBE are potentially useful tools for future product assessment.

• 出版日期2014-8