Atrial fibrillation, cognition and dementia: A review

作者：Aldrugh Summer; Sardana Mayank^*; Henninger Nils; Saczynski Jane S; McManus David D

来源：Journal of Cardiovascular Electrophysiology, 2017, 28(8): 958-965.

DOI：10.1111/jce.13261

• Alzheimer's disease
• anticoagulants
• atrial fibrillation
• cognitive decline
• dementia
• vascular dementia

Atrial fibrillation (AF) is one of the most common types of cardiac arrhythmia, particularly among older adults. AF confers a 5-fold risk for thromboembolic stroke as well as a 2-fold higher risk for congestive heart failure, morbidity, and mortality. Although stroke remains an important and impactful complication of AF, recent studies have shown that AF is independently associated with other neurological disorders, including cognitive impairment and dementia, even after adjusting for prior ischemic stroke. We performed a review of the published literature on the association between AF and cognitive status. Further, we reviewed studies investigating the underlying mechanisms for this association and/or reporting the impact of AF treatment on cognitive function. While most published studies demonstrate associations between AF and impaired cognition, no AF treatment has yet been associated with a reduced incidence of cognitive decline or dementia.

• 出版日期2017-8
• 单位东北大学