An approach to cannabinoids by radical cyclisation of 1,7-dienes using diethyl thiophosphite

作者：Healy Mark P; Parsons Andrew F^*; Rawlinson James G T

来源：Synlett, 2008, (3): 329-332.

DOI：10.1055/s-2008-1032049

• addition reactions
• cyclisations
• ethers
• radical reactions
• substituent effects

Various 1,7-dienes, prepared efficiently in five steps from salicylaldehyde, react with diethyl thiophosphite (in the presence of AIBN) to form substituted chromans, which are potential precursors to cannabinoids. The influence of the substitution of the 1,7-diene on the efficiency of the radical cyclisation is discussed.

• 出版日期2008-2-12