A Preliminary Randomized Controlled Trial of a Nurse-Delivered Medication Adherence Intervention Among HIV-Positive Outpatients Initiating Antiretroviral Therapy in Beijing, China

作者：Simoni, Jane M.; Chen, Wei-Ti; Huh, David; Fredriksen-Goldsen, Karen I.; Pearson, Cynthia; Zhao, Hongxin^*; Shiu, Cheng-Shi; Wang, Xin; Zhang, Fujie

来源：AIDS and Behavior, 2011, 15(5): 919-929.

DOI：10.1007/s10461-010-9828-3

• HIV/AIDS
• Adherence
• Counseling
• China
• Nursing

We evaluated a nurse-delivered adherence intervention in a preliminary randomized controlled trial among 70 HIV-positive outpatients initiating antiretroviral therapy (ART) in Beijing, China. In both arms, participants received a 30-min educational session, a pillbox, and a referral to a peer support group. In the enhanced arm, participants could choose an electronic reminder device, three sessions of counseling either alone or with a treatment adherence partner, or both reminder and counseling. Survey assessments and blood draws occurred at baseline, post-intervention (13 weeks), and follow-up (25 weeks). Primary outcomes were 7-day and 30-day adherence assessed by self-report and electronic drug monitoring (EDM), and secondary outcomes were HIV-1 RNA viral load and CD4 count. The intervention was feasible and well received. It led to some improvement in self-reported and EDM-assessed adherence but not the biological outcomes. Providing counseling and facilitating the use of electronic reminders to patients initiating ART merits further investigation as a culturally viable means of promoting adherence in China.

• 出版日期2011-7
• 单位中国疾病预防控制中心性病艾滋病预防控制中心; 北京地坛医院; 首都医科大学