Assembly of Alzheimer's A beta peptide into nanostructured amyloid fibrils

作者：Morgado Isabel; Faendrich Marcus

来源：Current Opinion in Colloid & Interface Science, 2011, 16(6): 508-514.

DOI：10.1016/j.cocis.2011.06.016

• Prion
• Protein folding
• Aggregation
• Inhibitor

The self-assembly of beta-amyloid (A beta) peptide into highly ordered amyloid fibril structures represents one of the pathological hallmarks of Alzheimer's disease. This process leads to the transient stabilization of ordered or disordered intermediates, which are thought to act as the main pathogenic culprits in neurodegenerative amyloid disease. This review describes recent results from different biophysical techniques, ranging from structure determination to single-particle methods by which the outgrowth of individual fibrils can be followed, and it explains their contributions towards understanding the mechanism of assembly. Finally, we will outline emerging methods and molecules to specifically interfere with the assembly and pathogenic impact of A beta, peptide.

• 出版日期2011-12