Association of 14-bp insertion/deletion polymorphism of HLA-G gene with unexplained recurrent spontaneous abortion: a meta-analysis

作者：Wang, X.; Jiang, W.^*; Zhang, D.

来源：Tissue Antigens, 2013, 81(2): 108-115.

DOI：10.1111/tan.12056

• HLA-G
• meta-analysis
• polymorphism
• unexplained recurrent spontaneous abortion

A meta-analysis was performed to assess the association of the human leukocyte antigen-G (HLA-G) 14?bp insertion (ins)/deletion (del) polymorphism with unexplained recurrent spontaneous abortions (URSA). The fixed or random effect pooled measure was selected based on the homogeneity test among studies that was evaluated with I2. Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of the association. In this meta-analysis, 14 studies with 1464 cases and 1247 controls corresponded to the inclusion criteria were included. Significant associations between 14?bp ins/del polymorphism and risk of URSA were observed in both dominant [random effect model (REM) OR?=?1.469, 95% CI?=?1.1271.914] and codominant (REM OR?=?1.195, 95% CI?=?1.0051.420) models. After excluding two articles that deviated from HardyWeinberg equilibrium in cases and sensitivity analysis, significant associations were also observed in dominant [fixed effect model (FEM) OR?=?1.224, 95% CI?=?1.0201.470] and codominant (FEM OR?=?1.158, 95% CI?=?1.0281.305) models. This meta-analysis suggests that the 14?bp ins HLA-G allele is associated with increased risk of URSA. The results are of importance to the clinical practice of URSA and infertility.

• 出版日期2013-2
• 单位青岛大学