Antireflux Surgery Preserves Lung Function in Patients With Gastroesophageal Reflux Disease and End-stage Lung Disease Before and After Lung Transplantation

作者：Hoppo Toshitaka; Jarido Veronica; Pennathur Arjun; Morrell Matthew; Crespo Maria; Shigemura Norihisa; Bermudez Christian; Hunter John G; Toyoda Yoshiya; Pilewski Joseph; Luketich James D; Jobe Blair A^*

来源：Archives of Surgery, 2011, 146(9): 1041-1047.

DOI：10.1001/archsurg.2011.216

Background: Gastroesophageal reflux disease (GERD) is common in patients with end-stage lung disease (ESLD). GERD may cause obliterative bronchiolitis after lung transplantation (LTx), represented by a decline in forced expiratory volume in 1 second (FEV1).
Objectives: To identify the patterns of reflux in patients with ESLD and to determine whether antireflux surgery (ARS) positively impacts lung function.
Design: Retrospective review of prospectively collected data.
Setting: Tertiary care university hospital.
Patients: Forty-three patients with ESLD and documented GERD (pre-LTx, 19; post-LTx, 24).
Interventions: Antireflux surgery.
Main Outcome Measures: Reflux patterns including laryngopharyngeal reflux as measured by esophageal impedance, and FEV1, and episodes of pneumonia and acute rejection before and after ARS.
Results: Before ARS, 19 of 43 patients (44%) were minimally symptomatic or asymptomatic. Laryngopharyngeal reflux events, which occurred primarily in the upright position, were common in post-LTx (56%) and pre-LTx (31%) patients. At 1 year after ARS, FEV1 significantly improved in 91% of the post-LTx patients (P<.01) and 85% of the pre-LTx patients (P=.02). Of patients with pre-ARS declining FEV1, 92% of post-LTx and 88% of pre-LTx patients had a reversal of this trend. Episodes of pneumonia and acute rejection were significantly reduced in post-LTx patients (P=.03) or stablilized in pre-LTx patients (P=.09).
Conclusions: There should be a low threshold for performing objective esophageal testing including esophageal impedance because GERD may be occult and ARS may improve or prolong allograft and native lung function.

• 出版日期2011-9