Antipsychotic drugs and obesity

作者：Correll Christoph U; Lencz Todd; Malhotra Anil K^*

来源：Trends in Molecular Medicine, 2011, 17(2): 97-107.

DOI：10.1016/j.molmed.2010.10.010

Mechanisms underlying antipsychotic cardiometabolic adverse effects are incompletely understood. This hampers the identification of high-risk patients, low-risk antipsychotics and preventive/ameliorative treatments. Recent clinical, molecular and genetic data suggest that: (i) antipsychotic-naive samples provide the greatest power for mechanistic studies; (ii) weight and metabolic effects can be discordant, pointing to overlapping and distinct mechanisms; (iii) antipsychotics affect satiety and energy homeostasis signaling; (iv) the specific peptides mediating these effects are unknown but probably overlap with those involved in idiopathic obesity; and (v) single nucleotide polymorphisms in genes encoding known neurotransmitter receptors and metabolic proteins are promising pharmacogenomic targets for countering adverse affects. However, sophisticated molecular studies and genome-wide association studies, ideally in antipsychotic-naive/first episode samples, are needed to further advance the field.

• 出版日期2011-2
• 单位河北医科大学