Dietary Slowly Digestible Starch Triggers the Gut-Brain Axis in Obese Rats with Accompanied Reduced Food Intake

作者：Hasek, Like Y.; Phillips, Robert J.; Zhang, Genyi; Kinzig, Kimberly P.; Kim, Choon Young; Powley, Terry L.; Hamaker, Bruce R.^*

来源：Molecular Nutrition & Food Research, 2018, 62(5): 1700117.

DOI：10.1002/mnfr.201700117

• food intake
• gut-brain axis
• meal size
• obesity
• slowly digestible starch

Scope: Slowly digestible starch (SDS), as a functional carbohydrate providing a slow and sustained glucose release, may be able to modulate food intake through activation of the gut-brain axis. @@@ Methods and results: Diet-induced obese rats were used to test the effect on feeding behavior of high-fat (HF) diets containing an SDS, fabricated to digest into the ileum, as compared to rapidly digestible starch (RDS). Ingestion of the HF-SDS diet over an 11-week period reduced daily food intake, through smaller meal size, to the same level as a lean body control group, while the group consuming the HF-RDS diet remained at a high food intake. Expression levels (mRNA) of the hypothalamic orexigenic neuropeptide Y (NPY) and Agouti-related peptide (AgRP) were significantly reduced, and the anorexigenic corticotropin-releasing hormone (CRH) was increased, in the HF-SDS fed group compared to the HF-RDS group, and to the level of the lean control group. @@@ Conclusion: SDS with digestion into the ileum reduced daily food intake and paralleled suppressed expression of appetite-stimulating neuropeptide genes associated with the gut-brain axis. This novel finding suggests further exploration involving a clinical study and potential development of SDS-based functional foods as an approach to obesity control.

• 出版日期2018-3
• 单位江南大学