An efficient, expeditious, and diastereoselective one-pot pseudo-five-component reaction for the synthesis of new bis-Betti bases under catalyst-free conditions

作者：Shafiee Mehdi; Khosropour Ahmad R^*; Mohammadpoor Baltork Iraj; Moghadam Majid; Tangestaninejad Shahram; Mirkhani Valiollah

来源：Tetrahedron Letters, 2012, 53(24): 3086-3090.

DOI：10.1016/j.tetlet.2012.04.037

• Bis-Betti base
• Condensation
• Multi-component reaction
• Aldehydes
• 3-Amino-5-methylisoxazole
• Dihydroxynaphthalene

A novel, diastereoselective, one-pot synthesis of new bis-Betti bases via condensation of dihydroxynaphthalene, two equivalents of aryl aldehydes, and two equivalents of 3-amino-5-methylisoxazole is reported. Conversion into the adducts was almost quantitative without the use of solvent or catalyst. The reaction conditions are very simple and enable easy isolation of the product.

• 出版日期2012-6-13