Multi-channel metabolic imaging, with SENSE reconstruction, of hyperpolarized [1-C-13] pyruvate in a live rat at 3.0 tesla on a clinical MR scanner

作者：Tropp James^*; Lupo Janine M; Chen Albert; Calderon Paul; McCune Don; Grafendorfer Thomas; Ozturk Isik Esin; Larson Peder E Z; Hu Simon; Yen Yi Fen; Robb Fraser; Bok Robert; Schulte Rolf; Xu Duan; Hurd Ralph; Vigneron Daniel; Nelson Sarah

来源：Journal of Magnetic Resonance, 2011, 208(1): 171-177.

DOI：10.1016/j.jmr.2010.10.007

• Hyperpolarization
• C-13
• Parallel imaging
• Rat
• In vivo
• Metabolic imaging

We report metabolic images of C-13, following injection of a bolus of hyperpolarized [1-C-13] pyruvate in a live rat. The data were acquired on a clinical scanner, using custom coils for volume transmission and array reception. Proton blocking of all carbon resonators enabled proton anatomic imaging with the system body coil, to allow for registration of anatomic and metabolic images, for which good correlation was achieved, with some anatomic features (kidney and heart) clearly visible in a carbon image, without reference to the corresponding proton image. Parallel imaging with sensitivity encoding was used to increase the spatial resolution in the SI direction of the rat. The signal to noise ratio in was in some instances unexpectedly high in the parallel images; variability of the polarization among different trials, plus partial volume effects, are noted as a possible cause of this.

• 出版日期2011-1