Timing of complementary food introduction and age at diagnosis of type 1 diabetes: the SEARCH nutrition ancillary study (SNAS)

作者：Crume T L^*; Crandell J; Norris J M; Dabelea D; Fangman M T; Pettitt D J; Dolan L; Rodriguez B L; O' Connor R; Mayer Davis E J

来源：European Journal of Clinical Nutrition, 2014, 68(11): 1258-1260.

DOI：10.1038/ejcn.2014.159

The association between timing of complementary food introduction and age at diagnosis of type 1 diabetes was investigated among 1077 children in the SEARCH for Diabetes in Youth study. Age at diagnosis was 5 months earlier for children introduced to sugar-sweetened beverages (SSB) in the first 12 months of life compared with those who were not (9.0 +/- 0.2 vs 9.5 +/- 0.1; P=0.02) independent of human leukocyte antigen (HLA) risk status. Analyses stratified by HLA risk status found that children with a high-risk HLA genotype had an earlier age at diagnosis if they were introduced to fruit juice in the first year of life (mean age at diagnosis = 9.3 +/- 0.1, 9.1 +/- 0.1 and 9.6 +/- 0.2 for introduction at %26lt;= 6 months, between 7 and 11 months and %26gt;= 12 months, respectively; P=0.04). Introduction of SSB in the first year of life may accelerate the onset of type 1 diabetes independent of HLA risk status.

• 出版日期2014-11