Dietary intake of fish and n-3 polyunsaturated fatty acids and risks of perinatal depression: The Japan Environment and Children's Study (JECS)

作者：Hamazaki Kei^*; Takamori Ayako; Tsuchida Akiko; Kigawa Mika; Tanaka Tomomi; Ito Mika; Adachi Yuichi; Saito Shigeru; Origasa Hideki; Inadera Hidekuni; Kishi Reiko; Yaegashi Nobuo; Hashimoto Koichi; Mori Chisato; Ito Shuichi; Yamagata Zentaro; Inadera Hidekuni; Kamijima Michihiro; Nakayama Takeo; Iso Hiroyasu; Shima Masayuki; Hirooka Yasuaki; Suganuma Narufumi; Kusuhara Koichi; Katoh Takahiko

来源：Journal of Psychiatric Research, 2018, 98: 9-16.

DOI：10.1016/j.jpsychires.2017.11.013

• n-3 polyunsaturated fatty acids
• Postpartum depression
• Psychological distress
• Pregnancy

The results of several epidemiological studies and clinical trials investigating the effects of n-3 polyunsaturated fatty acids (PUFAs) on antenatal and postnatal depression remain controversial. We investigated the possible association of dietary intake of fish and n-3 PUFAs with the risks of maternal and paternal psychological distress during pregnancy and of maternal postpartum depression in Japan. From a dataset comprising 104,102 maternal registrations and 52,426 paternal registrations in The Japan Environment and Children's Study, this study analyzed complete data on questionnaires for 75,139, 79,346, and 77,661 women during early pregnancy, mid late pregnancy, and after pregnancy, respectively, and for 41,506 male partners. Multivariable logistic regression showed reduced risk of psychological distress in the second and third quintiles for fish intake in early pregnancy and in the second to fifth quintile in mid-late pregnancy. No reductions were observed for n-3 PUFA intake in early pregnancy but in the second to fourth quintile in mid-late pregnancy. For postpartum depression, reductions were observed in the second to fourth quintile for fish intake but only in the first quintile for n-3 PUFA intake. As for paternal psychological distress, only the fourth quintile for fish intake showed a significant reduced risk but none were shown for n-3 PUFA intake. In conclusion, fish intake was associated with some reduced risk of psychological distress during pregnancy, even for male partners. The associations were weaker for n-3 PUFA intake than for fish intake.

• 出版日期2018-3