ASPEN Clinical Guidelines: Nutrition Support of Neonatal Patients at Risk for Metabolic Bone Disease

作者：Nehra Deepika; Carlson Sarah J; Fallon Erica M; Kalish Brian; Potemkin Alexis K; Gura Kathleen M; Simpser Edwin; Compher Charlene^*; Puder Mark

来源：Journal of Parenteral and Enteral Nutrition, 2013, 37(5): 570-598.

DOI：10.1177/0148607113487216

• neonates
• parenteral nutrition
• minerals/trace elements

Background: Premature infants are at increased risk for metabolic bone disease, with resulting delayed bone growth, osteopenia, and rickets. Method: A systematic review of the best available evidence to answer a series of questions regarding neonatal patients at risk of metabolic bone disease receiving parenteral or enteral nutrition was undertaken and evaluated using concepts adopted from the Grading of Recommendations, Assessment, Development and Evaluation working group. A consensus process was used to develop the clinical guideline recommendations prior to external and internal review and approval by the American Society for Parenteral and Enteral Nutrition Board of Directors. Questions: (1) What maternal risk factors predispose the neonate to metabolic bone disease? (2) What is the optimal type of feeding to promote neonatal bone health? (3) When and how should vitamin D supplements be administered? (4) Does parenteral nutrition (PN) predispose a neonate to metabolic bone disease, and if so, are there PN formulation recommendations to minimize this risk?

• 出版日期2013-9