Using bioluminescence imaging in glioma research

作者：Luwor Rodney B^*; Stylli Stanley S; Kaye Andrew H

来源：Journal of Clinical Neuroscience, 2015, 22(5): 779-784.

DOI：10.1016/j.jocn.2014.11.001

• Bioluminescence
• Glioblastoma multiforme
• Signalling
• Therapy

Glioblastoma multiforme (GBM) is the most common malignant brain tumour and has the worst prognosis. Over the last decade, the use of bioluminescence imaging technology has rapidly become widespread to further understand the mechanisms that drive GBM development and progression. Preclinical evaluation and optimisation of therapeutic efficacy in GBM research has also utilised this simple non-invasive technology. Here we summarise recent advances made in glioma biology and therapeutic intervention using bioluminescence imaging. This review also describes the current knowledge regarding the use of luciferase-based reporters in examining the role of specific cancer signalling cascades that promote glioma progression.

• 出版日期2015-5