Alpha-synuclein%26apos;s degradation in vivo Opening a new (cranial) window on the roles of degradation pathways in Parkinson disease

作者：Ebrahimi Fakhari Darius; McLean Pamela J^*; Unni Vivek K

来源：Autophagy, 2012, 8(2): 281-283.

DOI：10.4161/auto.8.2.18938

• neurodegeneration
• Parkinson disease
• Lewy bodies
• alpha-synuclein
• degradation
• autophagy
• lysosome
• proteasome
• in vivo
• multiphoton imaging

Progressive accumulation of alpha-synuclein is key to the pathology of many neurodegenerative diseases, including Parkinson disease and dementia with Lewy bodies. Increased intracellular levels of alpha-synuclein may be caused by enhanced expression or alterations in protein degradation pathways. Here we review our recent study showing that the ubiquitin-proteasome system and the autophagy-lysosomal pathway are differentially involved in alpha-synuclein%26apos;s degradation in vivo. We discuss the key findings obtained with our novel in vivo approach and also present a model for the progression of protein aggregation and dysfunctional degradation in Parkinson disease.

• 出版日期2012-2