A Novel Mechanism for Cyclic Adenosine Monophosphate-Mediated Memory Formation: Role of Amyloid Beta

作者：Ricciarelli Roberta; Puzzo Daniela; Bruno Olga; Canepa Elisa; Gardella Elena; Rivera Daniela; Privitera Lucia; Domenicotti Cinzia; Marengo Barbara; Marinari Umberto Maria; Palmeri Agostino; Pronzato Maria Adelaide; Arancio Ottavio; Fedele Ernesto^*

来源：Annals of Neurology, 2014, 75(4): 602-607.

DOI：10.1002/ana.24130

Cyclic adenosine monophosphate (cAMP) regulates long-term potentiation (LTP) and ameliorates memory in healthy and diseased brain. Increasing evidence shows that, under physiological conditions, low concentrations of amyloid (A) are necessary for LTP expression and memory formation. Here, we report that cAMP controls amyloid precursor protein (APP) translation and A levels, and that the modulatory effects of cAMP on LTP occur through the stimulation of APP synthesis and A production. Ann Neurol 2014;75:602-607

• 出版日期2014-4