Antioxidant constituents from the stems and fruits of Momordica charantia

作者：Lin Kai Wei; Yang Shyh Chyun^*; Lin Chun Nan

来源：Food Chemistry, 2011, 127(2): 609-614.

DOI：10.1016/j.foodchem.2011.01.051

• Momordica
• Cucurbitane-type triterpene glycoside
• Antioxidant
• Steroid glycoside

A new cucurbitane-type triterpene glycoside taiwacin A (1), a new 23,24,25,26,27-pentanorcucurbitane, taiwacin B (2) and a known cucurbitane-type triterpene glycoside (3), and a known steroid glycoside (4), were isolated from the stems and fruits of Momordica charantia, respectively. The structure of new compound was elucidated by spectroscopic methods. These four compounds, 1, 2, 3 and 4 revealed ABTS radical cation scavenging activity with an IC(50) values of 119.1 +/- 4.3, 204.5 +/- 1.2, 159.7 +/- 11.0 and 98.1 +/- 2.4 mu M, respectively. Compounds 1 and 3 displayed an inhibitory effect on xanthine oxidase (XO) activity with IC(50) values of 24.1 +/- 3.4 and 158.3 +/- 35.6 mu M, respectively. Compounds 2-4 significantly displayed O(2)(center dot-) scavenging activity with an IC(50) values of 12.5 +/- 2.2, 16.5 +/- 0.1 and 27.3 +/- 1.4 mu M, respectively and the relative oxygen radical absorbance capacity (ORAC) values of 2 and 3, using ORAC-pyrogallol red (PGR) assay, were determined to be 0.88 +/- 0.02 and 0.55 +/- 0.09, respectively. These findings showed that 1-4 may be used as antioxidants.

• 出版日期2011-7-15