A new and facile approach to 1,2-dihydroisoquinolin-3(4H)-imines by the Cu(I)-catalyzed reaction of 2-ethynylbenzyl methanesulfonates, sulfonyl azides and amines

作者：Huang, Ying; Yi, Weiyin^*; Sun, Qihui; Zhang, Lirong; Yi, Fengping^*

来源：RSC Advances, 2018, 8(1): 74-79.

DOI：10.1039/c7ra12412k

• ASYMMETRIC TRANSFER HYDROGENATION
• MULTICOMPONENT REACTION SYNTHESIS
• ONE-POT SYNTHESIS
• TERTIARY-AMINES
• ENANTIOSELECTIVE SYNTHESIS
• HIGHLY EFFICIENT
• RECENT PROGRESS
• ACCESS
• TETRAHYDROISOQUINOLINE
• ALKALOIDS

A new, step-economical and operationally simple access to unsubstituted 1,2-dihydroisoquinolin-3(4H)imines by Cu-catalyzed MCRs under mild conditions is described. In addition, selective hydrolysis of imines to the corresponding 1,2-dihydroisoquinolin-3(4H)-ones under refluxed conc. HCl has also been investigated.

• 出版日期2018
• 单位上海应用技术大学