A Screening Study of Potential Carcinogen Biomarkers After Surgical Treatment of Obesity

作者：de Siqueira Luciana Teixeira; Outtes Wanderley Marcela Silvestre; da Silva Roberto Afonso; Andrade Pereira Adriana da Silva; de Lima Filho Jose Luiz; Bandeira Ferraz Alvaro Antonio

来源：Obesity Surgery, 2018, 28(8): 2487-2493.

DOI：10.1007/s11695-018-3191-2

• Obesity
• Cancer
• Biomarkers
• Proteomics
• Two-dimensional electrophoresis
• Bariatric surgery

Obesity has been associated with the development of various types of cancer. Biomarker studies may provide molecular level knowledge of the factors involved in this association, improving clinical practice through new methods of prevention and treatment.
The present study aimed to analyze proteins found in the plasma of obese patients prior to and 6 months after bariatric surgery, using body mass index (BMI) and percentage total weight loss (%TWL) to evaluate, in a prospective manner, the effects of weight loss on the regulation of proteins related to the appearance of tumors.
This was a cohort study designed to compare parameters before and after intervention. A total of 40 patients were divided into two groups: control (n = 10) and obese (n = 30). The latter group was stratified according to surgical technique used (Roux-en-Y gastric bypass (RYGB) n = 11 and sleeve gastrectomy (SG) n = 19) to remove confounding variables. Blood samples were collected for plasma protein studies using two-dimensional electrophoresis.
Six proteins related to carcinogenesis were hyperexpressed in the obese patients but were absent in the control group and following surgery. These proteins were the beta-receptor of derived growth factor platelet, the receptor of apolipoprotein B, thrombospondin-2, the low-density lipoprotein receptor, transthyretin, and podoplanin.
The current preliminary study thus identified potentially carcinogenic proteins in obese patients. Surgical weight loss resulted in the not detection of these proteins.

• 出版日期2018-8