Association of PON1 and PON2 Polymorphisms with PON1 Activity and Significant Coronary Stenosis in a Tunisian Population

作者：Rejeb Jihene; Omezzine Asma; Rebhi Lamia; Boumaiza Imen; Mabrouk Hajer; Rhif Hamida; Ben Rejeb Nabila; Nabli Naoufel; Douki Wahiba; Ben Abdelaziz Ahmed; Boughzala Essia; Bouslama Ali^*

来源：Biochemical Genetics, 2013, 51(1-2): 76-91.

DOI：10.1007/s10528-012-9544-y

• PON1 and PON2 polymorphisms
• PON1 activity
• Significant coronary stenosis
• Tunisian

PON1 and PON2 have attracted considerable attention as candidate genes for coronary heart disease because their enzymes function as key factors in lipoprotein catabolism pathways. We studied the distribution of PON1 and PON2 polymorphisms, including genotyping, lipid profile, and PON1 activity, and their association with PON1 activity and significant coronary stenosis (SCS) in a Tunisian population. PON1 activity was lower in patients with SCS than in controls. It increased with the R allele (QQ < QR < RR) in PON1-192 genotypes and with the L allele (MM < ML < LL) in PON1-55 genotypes. In the presence of metabolic syndrome and diabetes, PON1-192RR and PON2-311CC were associated with an increased risk of SCS and PON1-55MM seems to have lower risk. This association was evident among nonsmokers for PON1-55MM and among smokers for PON1-192RR and PON2-311CC. The GTGC haplotype seemed to increase the risk of SCS compared with the wild haplotype in a Tunisian population.

• 出版日期2013-2