Association of parity with osteoprotegerin levels and atherosclerosis

作者：Eren Mehmet Ali^*; Vural Mehmet; Yildiz Sema; Cece Hasan; Camuzcuoglu Hakan; Toy Harun; Kocyigit Abdurrahim

来源：Archives of Gynecology and Obstetrics, 2013, 287(6): 1081-1086.

DOI：10.1007/s00404-012-2703-x

• Parity
• Carotid intima-media thickness
• Osteoprotegerin

Purpose Association of serum osteoprotegerin (OPG) levels and cardiovascular disorders has been shown previously. The aim of this observational study was to investigate the relationship between parity, OPG and carotid intima-media thickness (CIMT) in premenopausal women.
Methods A total of 128 women (mean age +/- SD, 37.8 +/- 4.7 years) were divided into three group according to parity [1-3 as group 1 (n = 41), 4-6 as group 2 (n = 55) and >= 7 as group 3 (n = 32)]. Serum OPG was measured and CIMT was evaluated.
Results Both serum OPG levels and CIMT tended to increase with advancing parity; OPG level was significantly higher in group 3 than in group 1 (p = 0.013) and CIMT was significantly higher in group 2 and group 3 than in group 1 (p < 0.001 for both). In correlation analyses, there were significant correlations between all three parameters.
Conclusions Our results revealed that there was an increased risk of cardiovascular disease in women with multiparity. Significant association of OPG with CIMT suggested that OPG might play a role in the pathogenesis of parity-induced atherosclerosis.

• 出版日期2013-6