Association of Dementia and Peptic Ulcer Disease: A Nationwide Population-Based Study

作者：Hsu Chih Chao; Hsu Yi Chao; Chang Kuang Hsi; Lee Chang Yin; Chong Lee Won; Lin Cheng Li; Kao Chia Hung^*

来源：American Journal of Alzheimer's Disease and Other Dementias, 2016, 31(5): 389-394.

DOI：10.1177/1533317515617546

• peptic ulcer disease
• dementia
• Taiwan National Health Insurance Research Database

Objective: We determine the association between dementia and the subsequent peptic ulcer disease (PUD).
Methods: We identified patients with diagnosed dementia in the Taiwan National Health Insurance Research Database. A comparison cohort without dementia was frequency-matched by age, sex, and comorbidities, and the occurrence of PUD was evaluated in both cohorts.
Results: The dementia and control cohort consisted of 6014 patients with dementia and 17 830 frequency-matched patients without dementia, respectively. The incidence of PUD (hazard ratio, 1.27; 95% confidence interval, 1.18-1.37; P < .001) was higher among patients with dementia. Cox models showed that being female, diabetes mellitus, chronic kidney disease, coronary artery disease, and chronic obstructive pulmonary disease were independent risk factors for PUD in patients with dementia.
Conclusion: Dementia might increase the risk of developing PUD.

• 出版日期2016-8
• 单位中国医科大学