科研之友
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摘要
Pesudorotaxanes/rotaxanes are an important class of supramolecules in the field of supramolecular chemistry. They can adjust their conformations under external stimuli, such as redox process, pH change, light, and solvent, and hence have been widely applied in the fabrication of molecular machines. Recently, researchers realized that these special structural features can be utilized to control drug release and enhance the ability of drugs to enter membranes, making these supramolecules promising candidates for drug carriers. In this paper, the progress of the application of pesudorotaxanes/rotaxanes in drug delivery systems over the past decade has been reviewed. In particular, two kinds of drug carriers, viz. pesudorotaxane-based mechanized silica nanoparticles (MSNP) and host-rotaxanes, are emphasized. MSNP was firstly designed and synthesized by Stoddart and Zink et al. Within MSNP, the assembly and de-assembly processes of the attached pesudorotaxanes endow silica nanoparticles with a new function-controlled drug release. The host-rotaxane carriers were fabricated by Smithrud et al. With the aid of shuttling processes in rotaxanes, host-rotaxanes hold a significant ability to penetrate biomembranes, which can be applied to aid transmembrane drug delivery. The advantages and disadvantages of these two kinds of drug carriers are discussed, either. Finally, the further development of pesudorotaxane/rotaxane-based drug carriers is prospected.
- 出版日期2013-5-24
- 单位南开大学
