Atopic dermatitis causes lipid accumulation in the liver of NC/Nga mouse

作者：Seino Satoshi; Tanaka Yurie; Honma Taro; Yanaka Miyuki; Sato Kenta; Shinohara Nahoko; Ito Junya; Tsuduki Tsuyoshi^*; Nakagawa Kiyotaka; Miyazawa Teruo; Ikeda Ikuo

来源：Journal of Clinical Biochemistry and Nutrition, 2012, 50(2): 152-157.

DOI：10.3164/jcbn.11-29

• allergy
• DNA microarray
• lipid metabolism
• liver
• NC/Nga

Various factors have been reported to influence lipid metabolism and cause metabolic syndrome. However, the influence of allergy on the liver that plays important role of lipid metabolism has not been clarified. The aim of this study was to examine the influence of allergy on lipid metabolism of liver. A model of atopic dermatitis was developed in the NC/Nga mouse using picryl chloride to induce allergy. Lipid metabolism parameters were measured and the mechanism of changes in these parameters was examined using DNA microarray analysis and quantitative reverse transcriptase PCR. Triacylglycerol accumulation was promoted in the liver in the mouse atopic dermatitis model despite reductions in food intake, body weight gain, and serum glucose. As this mechanism, it was thought that atopic dermatitis caused the suppression of fatty acid beta-oxidation. These results suggest that atopic dermatitis causes lipid accumulation in the liver.

• 出版日期2012-3-1