Nerve repair: Experimental and clinical evaluation of neurotrophic factors in peripheral nerve regeneration

作者：Johnson Elizabeth O^*; Charchanti Antonia; Soucacos Panayotis N

来源：Injury-International Journal of the Care of the Injured, 2008, 39: S37-S42.

DOI：10.1016/j.injury.2008.06.015

• NGF
• BDNF
• CNTF
• GDNF
• NT-3
• Neurotrophin
• Neurokines
• Transforming growth factor

Neurotrophic factors are a family of polypeptides required for survival of discrete neuronal populations. In the normal state such factors are mostly synthesised by target tissues and are used for the viability of the nerve-cell bodies. After nerve injury, neurotrophic factors (NFs) are synthesised by non-neuronal (Schwann cells and fibroblasts) in the nerve trunk, and act to support the outgrowth of axons. NFs can be classified into three major groups: (1) neurotrophins; (2) neurokines; and (3) the transforming growth factor beta (TGF)-beta superfamily.

• 出版日期2008-9