Anticancer activity of baicalein and luteolin studied in colorectal adenocarcinoma LoVo cells and in drug-resistant LoVo/Dx cells

作者：Palko Labuz Anna^*; Sroda Pomianek Kamila; Uryga Anna; Kostrzewa Suslow Edyta; Michalak Krystyna

来源：Biomedicine & Pharmacotherapy, 2017, 88: 232-241.

DOI：10.1016/j.biopha.2017.01.053

• Colon cancer
• Multidrug resistance
• Flavonoids
• Caspase 3
• PCNA
• RNAi

Due to the type-specific diversity of cancer cells, an analysis and elucidation of molecular mechanisms responsible for anticancer properties of biologically active compounds are essential. Plant-derived polyphenolic compounds such as flavonoids may be useful in cancer chemoprevention or treatment because they influence diverse molecular pathways in cancer cells.
In these studies anticancer activity of natural occurring flavones, baicalein and luteolin was investigated in colon cancer cells LoVo and in their drug resistant subline LoVo/Dx. Inhibitory activity of these flavones on cells growth and their ability to induce apoptosis were observed. A less pronounced influence of studied flavones on proliferation and apoptosis of LoVo/Dx as compared with LoVo cells well correlated with significantly lower cytotoxicity of these compounds in drug-resistant cells. These effects may be related to overexpression of multidrug transporter P-glycoprotein in drug-resistant LoVo/Dx cells. Our studies indicated that baicalein could be a substrate of this drug transporter.

• 出版日期2017-4