Brain-derived neurotrophic factor in the infralimbic cortex alleviates inflammatory pain

作者：Yue, Lupeng; Ma, Long-Yu; Cui, Shuang; Liu, Feng-Yu; Yi, Ming; Wan, You^*

来源：Neuroscience Letters, 2017, 655: 7-13.

DOI：10.1016/j.neulet.2017.06.028

• Brain derived neurotrophic factor
• Infralimbic cortex
• Prefrontal cortex
• Inflammatory pain

In chronic pain, it has been reported that the medial prefrontal cortex (mPFC) takes important regulatory roles, and may change functionally and morphologically in result of chronic pain. Brain-derived neurotrophic factor (BDNF) is well known as a critical modulator of neuronal excitability and synaptic transmission in the central nervous system. The aim of the present study is to investigate the role of BDNF in the infralimbic cortex and the prelimbic cortex of the mPFC in complete Freund's adjuvant (CFA)-induced inflammatory pain. We found that the BDNF level decreased in the infralimbic cortex, but not in the prelimbic cortex, 3 days after the CFA induction of the inflammatory pain. BDNF infusion into bilateral infralimbic cortices to activate neuronal activities could alleviate inflammatory pain and accelerate long-term recovery from pain. In conclusion, BDNF in the infralimbic cortex of the mPFC could accelerate recovery from inflammatory pain.

• 出版日期2017-8-10
• 单位北京大学